Ricerc@Sapienza

Si ipotizza un’applicazione di ICT su uno dei ponti romani ancora oggi presenti, anche se con una sola arcata, a Roma: Ponte Emilio o Ponte “Rotto”. L’ipotesi è quella di
consentire la visualizzazione del ponte e delle sue trasformazioni nel tempo attraverso una APP per “portable devices” (smartphone e tablet) di proprietà dei visitatori/turisti/studiosi/curiosi. Le possibilità offerte dalla Virtual e Augmented Reality permettono di visualizzare sull’oggetto inquadrato dalla fotocamera del “device” ipotesi ricostruttive statiche e dinamiche.

Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the development of Alzheimer Disease (AD). The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways, including insulin signaling and autophagy, involved in pathology onset and progression.

Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer’s disease (AD), flaws in the cerebral glucose uptake translate into reduced hexosamine biosynthetic pathway flux and subsequently lead to aberrant protein O-GlcNAcylation. Notably, the reduction of O-GlcNAcylated proteins involves also tau and APP, thus promoting their aberrant phosphorylation in AD brain and the onset of AD pathological markers.

recensione Saggi dedicati ai "libri mobili", dai manoscritti alle applicazioni digitali.