Ricerc@Sapienza

Background: To investigate the presence of laryngopharyngeal reflux in
patients with obstructive sleep apnea (OSA) employing the salivary pepsin
concentration method. To compare the results of pepsin concentration with the
severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31
females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea
index) and the BMI (body mass index) were initially evaluated. All the patients
enrolled were assessed using the reflux symptom index (RSI) and the reflux finding

Background: patients with laryngopharyngeal reflux (LPR) showed detectable levels of tear pepsin that explain the nasolacrimal obstruction. The purpose of this study was to determine whether patients with LPR show ocular surface changes and to investigate the relationship between lacrimal pepsin concentration and ocular alterations. Methods: Fifty patients with positive endoscopic signs for LPR and an equal or higher score of 13 and 7 for Reflux Symptom Index and Reflux Finding Score were enrolled.

Purpose: Laryngopharyngeal reflux (LPR) is a frequent condition in Obstructive Sleep Apnoea (OSA) patients and different studies have been published in the last years about this topic. A review of the published literature regarding LPR in OSA patients has been reported. A meta-analysis to evaluate the incidence of LPR in OSA patients and correlate LPR positivity with OSA patients' characteristics has been performed.