Ricerc@Sapienza

Introduction: Seroma formation represents one of the most frequent postoperative
complications of axillary dissection in breast cancer (BC) patients. We aimed to
retrospectively explore the effectiveness of the intraoperative use of a synthetic
cyanoacrylate glue (specifically Glubran®2) vs. the intraoperative use of a fibrin sealant
(specifically Tisseel) in reducing seroma formation compared to the use of nonsealant in
BC patients who underwent breast surgery and axillary dissection.

Late onset of fluid collection surrounding breast implants may represent a serious issue when considering the possibility of breast implant-associated anaplastic large cell lymphoma, a newly recognized type of T-cell malignancy. However, many other factors, including trauma and infections, may be implicated in the formation of non-neoplastic periprosthetic delayed effusions.

Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is an uncommon peripheral T cell lymphoma usually presenting as a delayed peri-implant effusion. Chronic inflammation elicited by the implant has been implicated in its pathogenesis. Infection or implant rupture may also be responsible for late seromas. Cytomorphological examination coupled with CD30 immunostaining and eventual T-cell clonality assessment are essential for BI-ALCL diagnosis. However, some benign effusions may also contain an oligo/monoclonal expansion of CD30 + cells that can make the diagnosis challenging.