Ricerc@Sapienza

Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis. Despite the TAVR, the patients with advanced valve disease and severe myocardial damage (low flow, gradient and ejection fraction)show high mortality level. Aim of this study was toevaluate the predicative power of a noninvasive and inexpensive test obtained by means of a simple standard 12-leads electrocardiogram,known as the Electrical Risk Score (ERS).

Degenerative aortic valve stenosis (AS) is associated to ventricular arrhythmias and sudden cardiac death, as well as mental stress in specific patients. In such a context, substrate, autonomic imbalance as well as repolarization dispersion abnormalities play an undoubted role. Aim of the study was to evaluate the increase of premature ventricular contractions (PVC) and complex ventricular arrhythmias during mental stress in elderly patients candidate to the transcatheter aortic valve replacement (TAVR).

Background and objectives: Electrical risk score (ERS) has been proposed as easy, inexpensive test to stratify of
sudden cardiac death (SCD) risk in subjects with normal left ventricular function. Potentially, aging, gender
and drugs can influence ERS affecting two on six electrical markers, particularly, those based on the repolarization.
Aim of this study was to establish aging, gender and drug therapy possible influences on ERS and mortality
in elderly patients.