BD Rhapsody™
Italiano
Questa piattaforma permette l’analisi contemporanea dei profili di espressione genica di migliaia di singole cellule, in popolazioni complesse derivate da fluidi biologici o da tessuto
single cell analysis
Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma
Originally described as interpatient variability, tumour heterogeneity has now been demonstrated to occur intrapatiently, within the same lesion, or in different lesions of the same patient. Tumour heterogeneity involves both genetic and epigenetic changes. Intrapatient heterogeneity is responsible for generating subpopulations of cancer cells which undergo clonal evolution with time. Tumour heterogeneity develops also as a consequence of the selective pressure imposed by the immune system.