Combination therapy of high-dose rabeprazole plus metronomic capecitabine in advanced gastrointestinal cancer: a randomized phase II trial
Abstract: Background: In recent years, proton pump inhibitors (PPIs) have been investigated at high-dose
tomodulate tumormicroenvironment acidification thus restoring chemotherapeutic sensitivity. This is the
first trial to study activity and safety of repurposing high dose rabeprazole combined with metronomic
capecitabine (mCAP). Methods: A phase II study in which patients with gastrointestinal cancer,
refractory to standard treatments, who had a life expectancy >3 months, were blind randomized