Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma.
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized
by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on
which cancer develops. Inflammation and the consequent fibro/cirrhosis, derived from chronic injuries of
several origins (viral, toxic and metabolic) and observable in almost all oncological patients, represents the
most powerful risk factor for HCC and, at the same time, an important obstacle to the efficacy of systemic