Ricerc@Sapienza

Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, transcriptional factors such as SNAIL, play critical roles in the EMT process. The interleukin (IL)-6/STAT3 axis has been related to enhanced glioblastoma's migration and invasion abilities as well.

Summarizing, the results of this study suggest that vitamin K deficiency is frequently observed in COVID-19 patients and that the deficit is greater in males than in females. In addition, in male patients, vitamin K deficiency is associated with a greater IL-6 level in the general circulation. In conclusion, we propose that vitamin K deficiency could support both cytokine storm Th2 by increasing proinflammatory cytokines such as IL-6, which is involved in the building up of the inflammatory response recruiting both cellular and humoral components.