intrahepatic cholangiocarcinoma

Tumor Microenvironment Research Group

Prof. Carmine Mancone is the director of the Tumor Microenvironment Research Group. This group works on understanding the molecular basis of the interaction between cancer cells and the tumor microenvironment (TME) in liver and biliary tract carcinomas.

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Free episomal and integrated HBV DNA in HBsAg-negative patients with intrahepatic cholangiocarcinoma

There is evidence that chronic hepatitis B virus (HBV) infection is associated with an increased risk of intrahepatic cholangiocarcinoma (ICC) development, and it has been hypothesized an etiological role of HBV in the development of this tumor. Very little is known about occult HBV infection (OBI) in ICC. Aims of the study were to investigate the OBI prevalence and to characterize the HBV molecular status at intrahepatic level in OBI-positive cases with ICC.

Italian practical clinical guidelines on cholangiocarcinoma: Part II, treatment

Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria.