noncoding RNA

Epigenetics of cellular differentiation and tumorigenesis

The research group focuses on epigenetics as a central driver of cellular differentiation and tumor development, with particular emphasis on hematologic malignancies. The research explores how epigenetic programs—based on DNA methylation, histone modifications, and non-coding RNA regulation—shape cell identity, plasticity, and, when disrupted, predisposition to malignancy. A major line of investigation examines how the epigenome governs hematopoietic maturation.

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Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer.