Gene expression profiles of oral soft tissue derived fibroblasts from healing wounds: correlation with clinical outcome, autophagy activation and fibrotic markers expression
Aim: Our aim was to evaluate gene expression profiling of fibroblasts from human alveolar mucosa (M), buccal attached gingiva (G) and palatal (P) tissues during early wound healing, correlating it with clinical response. Materials and Methods: M, G and P biopsies were harvested from six patients at baseline and 24 hrs after surgery. Clinical response was evaluated through Early Wound Healing Score (EHS). Fibrotic markers expression and autophagy were assessed on fibroblasts isolated from those tissues by Western blot and qRT‐PCR.