Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
Metabolic reprogramming provides critical information for clinical oncology. Using molecular
data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33
cancer types based on mRNA expression patterns of seven major metabolic processes and assessed
their clinical relevance. Our metabolic expression subtypes correlated extensively with clinical
outcome: subtypes with upregulated carbohydrate, nucleotide, and vitamin/cofactor metabolism