Degenerative disc disease | Ricerc@Sapienza

Histomorphology and immunohistochemical patterns in degenerative disc disease and clinical-radiological correlations. A prospective study

Degenerative disc disease (DDD) is a common condition causing low-back pain, disability and, eventually, neurological symptoms. This investigation aimed to investigate intervertebral disc DDD-related changes, evaluating histomorphology and cytokines secretion, and their clinical-radiological correlations.

Comparison of pure lateral and oblique lateral inter-body fusion for treatment of lumbar degenerative disk disease: a multicentric cohort study

Purpose: The most effective interbody fusion technique for degenerative disk disease (DDD) is still controversial. The purpose of our study is to compare pure lateral (LLIF) and oblique lateral (OLIF) approaches for the treatment of lumbar DDD from L1–L2 to L4–L5, in terms of clinical and radiological outcomes. Materials and methods: 45 patients underwent lumbar interbody fusion for pure lumbar DDD from L1–L2 to L4–L5 through LLIF (n = 31, mean age 62.1 years, range 45–78 years) or OLIF (n = 14, mean age 57.4 years, range 47–77 years).