phosphodiesterase 5-inhibitors

Molecular & Metabolic Endocrinology

We are exploring new players involved in the interplay between metabolism and intracrinology. Using a mixed basic and translational approach, we are fascinated by how the complexity of phosphodiesterases and intracellular hormonal metabolism can shape adipocytes, endothelial cells, smooth muscle cells, stem cells, and cancer cells response to challenges.

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Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors

Objectives: The aim of this study was to assess the prevalence of patients with Erectile Dysfunction (ED) receiving psychotropic drugs, the impact of these drugs on hormonal profile, and the efficacy of PDE5-i in these patients. Materials and methods: We recruited 1872 patients referring for ED to our Andrology Unit. Assessment included serum testosterone, gonadotropins, TSH, prolactin, and PSA, and the IIEF-5 questionnaire for ED diagnosis.