The secretin/secretin receptor axis modulates ductular reaction and liver fibrosis through changes in transforming growth factor (TGF)-β1-mediated biliary senescence
Activation of the secretin (Sct)/secretin receptor (SR) axis stimulates ductular reaction and liver fibrosis that are hallmarks of cholangiopathies. Our aim was to define the role of Sct-regulated cellular senescence and we demonstrated that both ductular reaction and liver fibrosis are significantly reduced in Sct-/-, SR-/-, and Sct-/-/SR-/- bile duct ligated (BDL) mice compared to BDL wild-type (WT) mice.