3D Bioprinted hydrogel model incorporating β-tricalcium phosphate for calcified cartilage tissue engineering
One promising strategy to reconstruct osteochondral defects relies on 3D bioprinted three-zonal structures comprised of hyaline cartilage, calcified cartilage, and subchondral bone. So far, several studies have pursued the regeneration of either hyaline cartilage or bone in vitro while – despite its key role in the osteochondral region – only few of them have targeted the calcified layer.