Ricerc@Sapienza

More than 60-80% of dementia cases worldwide in elderly people is caused by Alzheimer’s disease (AD) (Alzheimer’s disease Facts and Figures, 2017). Histopathologically, AD is characterized by the aggregation of extracellular neuritic β-amyloid peptide that leads to the creation of senile plaques, and the production of intracellular neurofibrillary tangles caused by tau protein hyperphosphorylation (Braak et al., 1988; Merz et al., 1983).

Alzheimer's disease (AD) is one of the most economically burdensome health conditions in current society that leads patients to functional disabilities. The main features of the disease are ?-amyloid plaques (SPs) and neurofibrillary tangles (NFTs) creation which causes neuronal and synaptic loss (Braak et al., 1988; Merz et al., 1983). During last decades, also astrocyte dysfunction and the presence of an intense inflammatory state have been considered further hallmarks of AD.