Relation of redox and structural alterations of rat skin in the function of chronological aging
Accumulation of oxidative insults on molecular and supramolecular levels could compromise renewal potency and architecture in the aging skin.
4-hydroxy-2-nonenal
Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal (HNE) is considered to be a strong marker of oxidative stress; the interaction between HNE and cellular proteins leads to the formation of HNE-protein adducts able to alter cellular homeostasis and cause the development of a pathological state. By virtue of its high lipid concentration, oxygen utilization, and the presence of metal ions participating to redox reactions, the brain is highly susceptible to the formation of free radicals and HNE-related compounds. A variety of neuropsychiatric disorders have been associated with elevations of HNE concentration.