ADAR1 | Ricerc@Sapienza

ADAR1

Immune Sensing and Surveillance Unit (IMMUSENSE)

My research focuses on understanding how the immune system detects and controls cancer cells, particularly in the context of cellular senescence and stress responses. By investigating the molecular mechanisms that regulate immune surveillance, we aim to identify new strategies to enhance immune recognition and clearance of cancer cells.

Current Funding

Exploring the potential of ADAR1 as a new immunotherapeutic target in cervical cancer
(AIRC Project IG 2021 – ID 25680)

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ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

Background: N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are two of the most abundant RNA modification events affecting adenosines in mammals. Both these RNA modifications determine mRNA fate and play a pivotal role in tumor development and progression.