Ricerc@Sapienza

Introduction. Medulloblastoma is the most common malignant brain tumor in children, but
accounts for only 1% of brain cancers in adults. For standard-risk pediatric medulloblastoma,
current therapy includes craniospinal irradiation (CSI) at reduced doses (23.4 Gy) associated with
chemotherapy. Whereas most same-stage adult patients are still given CSI at 36 Gy, with or
without chemotherapy, we report here on our use of reduced-dose CSI associated with
chemotherapy for older patients. Methods. We gathered non-metastatic patients over 18 years

Medulloblastoma is a highly aggressive brain tumor that typically affects children, while in adults it represents ~1% of all brain tumors. Little is known about microRNA expression profile of the rare adult medulloblastoma. The main aim of this study was to identify peculiar differences in microRNA expression between childhood and adult medulloblastoma. Medulloblastomas were profiled for microRNA expression using the Exiqon Human miRNome panel (I + II) analyzing 752 microRNAs in a training set of six adult and six childhood cases.