Ricerc@Sapienza

Patients with Coronavirus-associated disease-2019 (COVID-19) display alterations of the hemostatic system and the presence
of a prothrombotic status frequently leading to vascular complications. However, the impact of COVID-19 on platelet
activity, aggregation and agglutination still needs to be clarified. We measured total levels of von Willebrand factor (vWF)
and vWF binding to the platelet glycoprotein (Gp) complex (GPIb-IX-V), in a cohort of COVID-19 patients admitted to the

Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated.