Aggressive pituitary adenomas

Oncological Endocrinology

Oncological Endocrinology

Working in the largest University Hospital in central Italy, we are a referral center for oncological patients suffering from a variety of tumors and/or developing endocrine complications. This comprises a lot of clinical work that gives us the opportunity to improve their quality of life, morbidity and mortality. We strive to give the most to our patients, and they give back energy, motivation and their happy participation in several clinical studies.

Stereotactic reirradiation with temozolomide in patients with recurrent aggressive pituitary tumors and pituitary carcinomas

Objectives: To evaluate the efficacy of a second course of fractionated stereotactic radiotherapy (re-SRT) and temozolomide (TMZ) as salvage treatment option in patients with aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs). Patients and Methods: Twenty-one patients with recurrent or progressive APTs (n = 17) and PCs (n = 4) who received combined TMZ and re-SRT, 36 Gy/18fractions or 37.5 Gy/15fractions, were retrospectively evaluated.

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