In Escherichia coli, the synthesis of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, takes place through the so-called deoxyxylulose 5-phosphate-dependent pathway, whose last step is pyridoxine 5'-phosphate (PNP) oxidation to PLP, catalyzed by the FMN-dependent enzyme PNP oxidase (PNPOx).
HIV persistent infection requires a life-long treatment and among the 2.1 million new
HIV infections that occur every year there is an increased rate of transmitted drugresistant
mutations. This fact requires a constant and timely effort in order to identify
and develop new HIV inhibitors endowed with innovative mechanisms. The HIV-1
Reverse Transcriptase (RT) associated Ribonuclease H (RNase H) is the only viral
encoded enzymatic activity that still lacks an efficient inhibitor despite the fact that it
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