Ricerc@Sapienza

Oregonin is an open-chain diarylheptanoid isolated from Alnus incana bark that possesses remarkable antioxidant and anti-inflammatory properties, inhibits adipogenesis, and can be used in the prevention of obesity and related metabolic disorders. Here, we aimed to investigate the effects of oregonin on the epigenetic regulation in cells as well as its ability to modulate DNA methylating enzymes expression and mitochondrial DNA (mtDNA) copies.

The development and decline of alder floodplain forests and alder carrs along the Tyrrhenian coasts, in relation to sea level changes, geomorphological processes, human activity, and climate change are presented and discussed. A number of 22 pollen records, complemented by Alnus macrofossil data, document the presence of widespread alder populations in the coastal Tyrrhenian floodplains throughout the Holocene, although with different density from one site to the other, mostly depending on local hydrological conditions.