Alpha 1 antitrypsin

Cell biology of the serpinopathies

We study a group of protein conformational diseases caused by polymerisation of mutant serpins (serin proteinase inhibitors), specifically the neuronal protein neuroserpin and the hepatic serpin alpha-1 antitrypsin. The mechanism of inhibition of serpins requires a high molecular flexibility that renders them very sensitive to destabilising mutations.

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Homocysteinylated alpha 1 antitrypsin as an antigenic target of autoantibodies in seronegative rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a chronic autoimmune disease and rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are the most frequently detected autoantibodies (autoAbs). To date, more than 20% of RA cases are still defined as seronegative forms (seronegative RA, SN-RA). The aim of this study was to identify new antigenic targets of autoAbs in RA patients, which can also be recognized in SN-RA. Using a proteomic approach, we tested sera from SN-RA patients by analyzing synovial fluid (SF) proteins from these patients.