Cisplatin and transplatin interaction with methionine: bonding motifs assayed by vibrational spectroscopy in the isolated ionic complexes
Cisplatin and transplatin (cis- and trans-[PtCl2(NH3)2]) have been allowed to react with methionine (Met)
in water solution in a study aimed to characterize the monofunctional complex primarily formed. The
thioether function of methionine is known to have a very high affinity for square planar platinum(II) and
sulfur-containing biomolecules have been proposed as a cisplatin drug reservoir on the way to
platination at DNA. Both cisplatin and transplatin yield [PtCl(NH3)2Met]+ complexes, delivered by