Cannabinoid drugs often induce biphasic effects on cognitive and emotional behavior depending on the level of stress and emotional arousal at the time of drug consumption. The effects of stress on endocannabinoids appear to be regionally specific and time-dependent relative to exposure to stress. Stress-induced changes in corticosterone affect memory.
Cannabinoid drugs often induce biphasic effects on cognitive and emotional behavior depending on the level of stress and emotional arousal at the time of drug consumption. The effects of stress on endocannabinoids appear to be regionally specific and time-dependent relative to exposure to stress. Stress-induced changes in corticosterone affect memory.
Exposure to a traumatic event may result in the development of post-traumatic stress disorder (PTSD). Endocannabinoids are crucial modulators of the stress response, interfere with excessive retrieval and facilitate the extinction of traumatic memories. Exposure therapy, combined with pharmacotherapy, represents a promising tool for PTSD treatment. We investigated whether pharmacological manipulations of the endocannabinoid system during extinction learning ameliorates the behavioral changes induced by trauma exposure.
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