Isotopic metabolic fractionation of endogenous steroids by 5α-reductase inhibitors
5α-Reductase inhibitors are drugs commonly used in the treatment of benign prostatic hyperplasia, androgenic alopecia and hirsutism. The only two pharmaceutical product commercially available and FDA-approved for clinical purpose are Finasteride and Dutasteride. They are both synthetic 4-azasteroids that irreversibly inhibit the 5α-reductase, competing against the substrate,