Inhibition of the ?-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties
We discovered novel and selective sulfonamides/amides acting as inhibitors of the a-carbonic anhydrase
(CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA). This Gram-negative bacterium is
the causative agent of cholera and colonises the upper small intestine where sodium bicarbonate is present
at a high concentration. The secondary sulfonamides and amides investigated here were potent, low
nanomolar VchCA inhibitors whereas their inhibition of the human cytosolic isoforms CA I and II was in