Ricerc@Sapienza

Antimicrobial resistance is one of the most serious global public health problems. Therefore, novel strategies are needed to counteract bacterial resistance development. The aim of the present study was to enhance the activity of antibiotics to bacteria by using ultrasound. Ultrasound reduced the dosage of ampicillin required to impair bacterial viability.

Sinceancienttimes,medicinalplantshavetraditionallybeenusedforthetreatment of different diseases. Nowadays, plants are considered a valuable source of unique natural compounds used in the development of antidiabetic, anti-inflammatory, anticancerous,andantimicrobialdrugs.Bacteria,fungi,andvirusesareresponsible for a range of human diseases. Microbial invasion and its virulence can cause damage to the host cells. Effective antimicrobials have been developed over the years; however, a dramatic increase in resistance to antimicrobial drugs has been observed.

BACKGROUND: Our research was focused on the analysis of the antimicrobial and antibiofilm power of two commonly used oral toothpastes containing different concentrations of fluorine. These toothpastes were tested in vitro on deciduous teeth. METHODS: Culture of S. mutans was inoculated in 1 mL of sterile phosphate buffered saline (PBS) with a 5% of toothpaste concentration with 500ppm e1400ppm of fluorine. The ability of the bacteria to form colonies was measured by counting the number of Colony Forming Units (CFU).

Microorganisms often cause significant damage on historical objects. The archive or library materials as well as textile or leather artifacts suffer serious attacks that need appropriate care treatments. Several biocide processes have been implemented but often their application does not preserve the material of the good. The objective of this work is the disinfection through ionizing radiation of leather wallpaper from the museum building Palazzo Chigi in Ariccia (Rome, Italy).

The colonization of microorganisms and their subsequent interaction with stone
substrates under different environmental conditions encourage deterioration of materials by multiple
mechanisms resulting in changes in the original color, appearance and durability. One of the emerging
alternatives to remedy biodeterioration is nanotechnology, thanks to nanoparticle properties such
as small size, no-toxicity, high photo-reactivity, and low impact on the environment. This study

Biofilm resistance to antimicrobials is a complex phenomenon, driven not only by genetic mutation induced resistance, but also by means of increased microbial cell density that supports horizontal gene transfer across cells. The prevention of biofilm formation and the treatment of existing biofilms is currently a difficult challenge; therefore, the discovery of new multi-targeted or combinatorial therapies is growing.

Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of S. molle L. male and female plants were investigated for the antimicrobial activity. Leaf extracts were tested on microbes Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Bacillus subtilis.