Characterization of transcription termination associated-RNAs (TTSa-RNAs): new insights into their biogenesis, tailing and expression in primary tumors
Next-generation sequencing has uncovered novel classes of small RNAs(sRNAs)in eukaryotes,in 30addition to the well-known miRNAs, siRNAs and piRNAs.In particular, sRNAspeciesarise from 31transcription start sites (TSSs) and the transcription termination sites (TTSs) of genes. However, a 32detailed characterization of these new classes of sRNAs is still lacking.