Artemisinin derivatives with antimelanoma activity show inhibitory effect against human dna topoisomerase 1
Artesunic acid and artemisinin are natural substances with promiscuous anticancer activity against different types of
cancer cell lines. The mechanism of action of these compounds is associated with the formation of reactive radical species by
cleavage of the sesquiterpene pharmacophore endoperoxide bridge. Here we suggested topoisomerase 1 as a possible molecular
target for the improvement of the anticancer activity of these compounds. In this context, we report that novel hybrid and dimer