Autoimmune diabetes

Molecular and pathophysiological heterogeneity of autoimmune diabetes: implications for precision medicine

Molecular and pathophysiological heterogeneity of autoimmune diabetes: implications for precision medicine

People with autoimmune diabetes (AD) are at higher risk of death due to the development of its acute and long-term sequelae. The process towards a cure for AD should encompass the identification of new pathways to prevent beta-cell failure and complications. A deep knowledge of AD heterogeneity is essential to understand and tackle the processes leading to disease onset and progression.

Adult-onset autoimmune diabetes in 2020: An update

An increasing number of new cases of autoimmune diabetes occur during adulthood. Most are cases of latent autoimmune diabetes in adults (LADA), a form of autoimmune diabetes with older mean age at onset, slower rate of beta-cell loss and longer period of insulin independence after onset when compared with type 1 diabetes. Unfortunately, patients with LADA are often misdiagnosed as having type 2 diabetes, the most frequent form of adult-onset diabetes, and show a sustained poor glycemic control over time.

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