Axon regeneration

Neurobiologia Cellulare

Neurobiologia Cellulare

Our research investigates the mechanisms underlying cellular recovery, with a particular emphasis on the role of nutrients as active modulators of repair and adaptation processes, especially in neural models exposed to oxidative stress or harboring rare metabolic mutations. We study how micronutrients—at both physiological and pharmacological doses—affect neural-like cells, focusing on metabolism as a potential upstream modulator rather than a downstream consequence.

NGF-dependent axon growth and regeneration are altered in sympathetic neurons of dystrophic mdx mice

Duchenne muscular dystrophy (DMD) is a lethal disease, determined by lack of dystrophin (Dp427), a muscular cytoskeletal protein also expressed by selected neuronal populations. Consequently, besides muscular wasting, both human patients and DMD animal models suffer several neural disorders. In previous studies on the superior cervical ganglion (SCG) of wild type and dystrophic mdx mice (Lombardi et al. 2008), we hypothesized that Dp427 could play some role in NGF-dependent axonal growth, both during development and adulthood.

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