Circulating miRNA-375 levels are increased in autoantibodies-positive first-degree relatives of type 1 diabetes patients
Growing evidence suggests that microRNAs (miRNAs) play a key role in beta-cell metabolism, proliferation and apoptosis, and in immune system functions, all processes involved in the pathogenesis of type 1 diabetes.
In the context of diabetes, particular attention has been focused on miR-375, which has been studied most extensively as a putative biomarker of beta cell death. Although dysregulated miRNA profiles have been identified in type 1 diabetes patients, results are inconclusive.