Ricerc@Sapienza

We read with interest the paper by Hamada et al.1 (covered vs uncovered metal stents for malignant gastric outlet obstruction. Systematic review and metaanalysis”).
We prospectively analyzed the clinical outcomes of 72 patients2,3 and we came to similar conclusions. Conceptually, covered stents present the advantage of preventing tumor ingrowth within the stent and, being more compliant, they could facilitate pyloric motility. However, they dislodge
more easily, and distal migration of the stent can lead to serious consequences ...

The quest for sustainable chemistry is fortunately an unstoppable process, and a new class of
biodegradable compounds, the Deep Eutectic Solvents (DES) [1,2], has recently been proposed as
inexpensive and “greener” alternative to flank the family of solvents currently considered the “pillar” of
solution green chemistry—ionic liquids. Such a new class is composed of an eutectic mixture of
solids, usually the quaternary ammonium salt choline chloride, and a hydrogen-donor (HBD) Brønsted