Ricerc@Sapienza

Materials for the treatment of cancer have been studied comprehensively over the past few decades. Among the various kinds of biomaterials, polymer-based nanomaterials represent one of the most interesting research directions in nanomedicine because their controlled synthesis and tailored designs make it possible to obtain nanostructures with biomimetic features and outstanding biocompatibility.

Il Progetto NTT mira allo sviluppo e la prototipazione di un sistema di training neurochirurgico ed anatomico utile, da un lato, alla formazione di neurochirurghi poco esperti a livello operatorio, dall’altro, alla formazione di studenti in relazione alle caratteristiche strutturali del sistema nervoso. Per gli studenti di medicina e chirurgia è infatti indispensabile fare pratica di dissezione, soprattutto per quel che concerne lo studio dell’anatomia.

Zinc oxide (ZnO) nanoparticles were synthesized on diatomite (DE) surface by a low
temperature sol gel technique, starting from zinc acetate dihydrate (Zn(CH3COO)2?·?2H2O)
solution in water/ethyl alcohol, in presence of triethanolamine (TEA) with functions of Zn2+
chelating agent, catalyst and mediator of nanoparticle growth on DE surface. Microstructural
features were investigated by field emission scanning electron microscopy and x-ray diffraction.
ZnO crystalline nanoparticles, well distributed both on the surface and into the porous

Brewers' spent grain (BSG) is the most abundant by-product of the brewing process. BSG is currently disposed of or used as a supplement for animal feed, although it contains significant amounts of bioactive compounds of great interest to the pharmaceutical, cosmetic and food sectors. In this study we investigate the feasibility of using a simple solvent extraction procedure to recover phenolic antioxidants from BSG. Acetone-water and ethanol-water mixtures were used as extraction solvents.

Aftermyocardial infarction, the heart’smechanical properties and its intrinsic capability to recover are
compromised.To improve this recovery, several groups have developed cardiac patches based on different
biomaterials strategies.Here, we developed polyvinylalcohol/dextran (PVA/Dex) elastic hydrogel patches,
obtained through the freeze thawing (FT) process, with the aimto deliver locally a potent natural
antioxidantmolecule, astaxanthin, and to assist the heart’s response against the generatedmyofibril stress.

Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellantransfersomes obtained by an easy, scalable method. The vesicles were small in size (similar to 107 nm) and monodispersed (P.I.

Today, early disease detection (EDD) is a matter of more importance than ever in medicine. Upon interaction with human plasma, nanoparticles are covered by proteins leading to formation of a biomolecular corona (BC). As the protein patterns of patients with conditions differ from those of healthy subjects, current research into technologies based on the exploitation of personalized BC patterns could be a turning point for early disease detection. Here, we present a framework based on principal component analysis of large personalized BC datasets.