Ricerc@Sapienza

Photonic crystal (PC)-enhanced fluorescence has been proposed as a novel tool for early disease detection in liquid biopsy. Photobleaching of the emitters has never been deeply investigated, although its cross section is expected to increase because of the large field intensity enhancement in PC. Herein, we report on the experimental investigation of the anisotropic effects arising when fluorescence excitation and emission are coupled to differently polarized modes of the same PC structure.

Photonic crystal (PC) enhanced fluorescence has been proposed as a novel tool for early disease detection in a liquid biopsy format. However, photobleaching of the emitters has never been deeply investigated, although its cross section is expected to increase due to the large field intensity enhancement. Herein, we report on a comprehensive theoretical description of the stationary fluorescence emission of molecular emitters bound to the surface of a one-dimensional photonic crystal (1DPC) biosensor.

The ability to merge electronic devices with biological systems at the cellular scale is an interesting perspective. Potential applications span from investigating the bio-electric signals in excitable (and non-excitable) cells with an insofar-unreached resolution to plan next-generation therapeutic devices. Semiconductor nanowires (NWs) are well suited for achieving this goal because of their intrinsic size and wide range of possible configurations.

Many research efforts over the last decade have been devoted to the development of microneedle-based diagnostic devices for minimally invasive transdermal biosensing and for long-term health monitoring. Transdermal biosensing via microneedle allows the development of minimally invasive easy-to-use point-of-care biodevices. The main objective of this short review is to provide a general overview of the most immediate and relevant progress in microneedle-based transdermal biosensing in the last five years. A critical analysis of the recent literature is finally presented.