Ricerc@Sapienza

The applications of peptide-based materials are currently expanding, especially in the biomedical field. The biocompatibility and biodegradability of peptide materials, as well as their ability to assemble into ordered secondary structures, are indeed ideal for biotechnological applications. However, their full potential will be exploited once novel synthetic procedures are developed for advanced applications. In this work, we explored the ability of Pseudomonas fluorescens lipase to biosynthesize the self-assembled tetrapeptide FmocPheGlyPhe2 for tissue regeneration.

In this article the scientific activity carried out on stemarane diterpenes and diterpenoids, isolated over the world from various natural sources, was reviewed. The structure elucidation of stemarane diterpenes and diterpenoids was reported, in addition to their biogenesis and biosynthesis. Stemarane diterpenes and diterpenoids biotransformations and biological activity was also taken into account. Finally the work leading to the synthesis and enantiosynthesis of stemarane diterpenes and diterpenoids was described.