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Molecular & Metabolic Endocrinology

We are exploring new players involved in the interplay between metabolism and intracrinology. Using a mixed basic and translational approach, we are fascinated by how the complexity of phosphodiesterases and intracellular hormonal metabolism can shape adipocytes, endothelial cells, smooth muscle cells, stem cells, and cancer cells response to challenges.

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INHIBITION OF THE NRF2/KEAP1 AXIS: A PROMISING THERAPEUTIC STRATEGY TO ALTER REDOX BALANCE OF CANCER CELLS

The NRF2/KEAP1 pathway is a crucial and highly conserved defensive system required to maintain or restore the intracellular homeostasis in response to oxidative, electrophilic and other types of stress conditions. The tight control of NRF2 function is maintained by a complex network of biological interactions between positive and negative regulators that ultimately ensure context specific activation, culminating in the NRF2-driven transcription of cytoprotective genes.

Influence of dynamic flow environment on nanoparticle-protein corona: From protein patterns to uptake in cancer cells

The fast growing use of nanoparticles (NPs) in biotechnology and biomedicine raises concerns about human health and the environment. When introduced in physiological milieus, NPs adsorb biomolecules (especially proteins) forming the so-called protein corona (PC). As it is the PC that mostly interacts with biological systems, it represents a major element of the NPs’ biological identity with impact on nanotoxicology, nanosafety and targeted delivery of nanomedicines.

The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability

Aged garlic extract (AGE) has been shown to possess therapeutic properties in cancer; however its mechanisms of action are unclear. In this study, we demonstrate by MTT assay that AGE exerts an anti-proliferative effect on a panel of both sensitive and multidrug-resistant (MDR) human cancer cell lines and enhances the effects of hyperthermia (42C) on M14 melanoma cells.