Effects of the metronomic treatment of ?-caryophyllene in combination with lowdose doxorubicin in liver cancer cells.
Standard chemotherapy scheduling requires the administration of maximum tolerated doses of anticancer drugs to reach a good therapeutic efficacy and is often responsible for various side effects and chemoresistance development. A metronomic chemotherapy, based on the repeated administration and/or continuous infusion of low doses of the anticancer drug, has been proposed as an alternative strategy to the standard protocol, due to its more favourable pharmacokinetic and pharmacodynamic profiles.