Old neurochemical markers, new functional directions?: an editorial for ‘Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain’ on page 650
The dorsal striatum coordinates input-output processing of numerous functions including those related to motor activity, motivation, and learning. Considerable anatomical and biochemical heterogeneity across striatal subregions has long been known to result in distinct functional outcomes, and for imbalances in these pathways to contribute to many complex disorders.