Ricerc@Sapienza

The most common subtype of renal cell carcinoma (RCC) is clear cell RCC (ccRCC).
It accounts for 70-80% of all renal malignancies representing the third most common
urological cancer after prostate and bladder cancer. The identification of non-invasive
biomarkers for the diagnosis and responsiveness to therapy of ccRCC may represent
a relevant step-forward in ccRCC management. The aim of this study is to evaluate
whether specific miRNAs deregulated in ccRCC tissues present altered levels also

Background: Kidney cancer and clear cell renal carcinoma (ccRCC) are the 16th most common cause of death worldwide. ccRCC is often metastasized at diagnosis, and surgery remains the main treatment; therefore, early diagnosis and new therapeutic strategies are highly desirable. KAT inhibitor CPTH2 lowers histone H3 acetylation and induces apoptosis in colon cancer and cultured cerebellar granule neurons. In this study, we have evaluated the effects of CPTH2 on ccRCC 786-O cell line and analyzed drug targets expressed in ccRCC tumor tissues at different grade.