Understanding the expression profile of efflux pumps during the intracellular life of Shigella
In several bacterial pathogens, efflux pumps, besides exporting antimicrobial agents, play a
role in bacterial pathogenicity.
Shigella, the causative agent of bacillary dysentery, during its evolution towards pathogenicity,
has conserved 14, out of 20 present in the genome of its commensal ancestor Escherichia coli,
operons encoding efflux pumps systems.
The aim of this work is to analyze the induction of efflux pumps conserved in Shigella
during the infection of macrophages and epithelial cells and to identify those that are potentially