Ricerc@Sapienza

There is emerging evidence that early uterine development in humans is an important determinant of conditions such as ontogenetic progesterone resistance, menstrual preconditioning, defective deep placentation and pre-eclampsia in young adolescents. A keyobservation is the relative infrequency of neonatal uterine bleeding and hormone withdrawal at birth. The origin of the uterus from the fusion of the two paramesonephric, or Mu¨llerian, ducts was described almost 200 years ago. The uterus forms around the 10th week of foetal life.

Background: Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-
Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble
other neoplastic or inflammatory conditions.
Case presentation: Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell
lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and

Introduction: Steroid hormones are responsible for specific changes in the endometrium during the menstrual cycle, when they are sequentially secreted and, because of this, in the early days sequential combined oral contraceptive regimens were utilized. The same basic concept has been utilized with multi-phasic regimens, in order to produce endometrial pictures mimicking the normal cycle.