d-mannose treatment neither affects uropathogenic Escherichia coli properties nor induces stable FimH modifications
Abstract: Urinary tract infections (UTIs) are mainly caused by uropathogenic Escherichia coli (UPEC).
Acute and recurrent UTIs are commonly treated with antibiotics, the efficacy of which is limited by the
emergence of antibiotic resistant strains. The natural sugar d-mannose is considered as an alternative
to antibiotics due to its ability to mask the bacterial adhesin FimH, thereby preventing its binding to
urothelial cells. Despite its extensive use, the possibility that d-mannose exerts “antibiotic-like” activity