Curcuminoids-loaded liposomes: influence of lipid composition on their physicochemical properties and efficacy as delivery systems
An extract of Curcuma longa containing mainly curcumin was included in liposomes formulated with phospholipids differing for the length of the acyl chains, the charge of the polar headgroup or the degree of unsaturation in the presence and in the absence of cholesterol. In fact, even if it is well known that liposomal curcuminoids are more stable and can be solubilized in aqueous media, a systematic approach that correlates the molecular structure of liposomes components to the physicochemical and biological behavior of the vescicles including curcumin and its derivatives is not described.