Ricerc@Sapienza

Teucrium polium L. is a species with ancient ethno-botanical uses for its anti-inflammatory action whichis mainly due to the phenolics content. On the other side, the presence of neo-clerodanes, which exerthepatotoxic action, may explain why in recent years the medicinal uses of this species have drasti-cally diminished. In this paper we report on the isolation of a new natural neo-clerodane diterpenoid,namely 20-O-acetyl-teucrasiatin (2), together with other twelve relevant compounds in the fields ofchemotaxonomy and ethnomedicine.

In this work, the first phytochemical analysis on the seeds of Nigella sativa L. collected from a new population in Iran is reported. The study was carried out by means of classical column chromatography and spectroscopic techniques and evidenced the presence of twenty-six compound divided into six different classes of natural compounds. In particular, compounds (3–4) have been reported in the family for the first time. In addition to this, the first NMR semi-quantitative analysis on their most polar metabolites content was reported.

In this work, the phytochemical profile of the ethanolic extract of Euphorbia peplus L. collected in CentralItaly, was reported. This specimen had never been studied before and the analysis was accomplished bymeans of Column Chromatography for the separation procedure and by means of NMR Spectroscopy andMass Spectrometry for the identification step. In particular, fourteen compounds were evidenced belong-ing to five different classes of natural compounds i.e.

In this work, the first phytochemical analysis ever performed on the unripe female cones of Wollemia nobilis W. G. Jones, K. D. Hill & J. M. Allen was described. The analysis evidenced the presence of a new derivative of sandaracopimaric acid together with rare diterpenoid derivatives and known compounds of chemosystematic and bioactivity relevance. Some of these were evidenced in the species or in the family for the first time during this study. The further implications of the isolated compounds in the field of chemosystematics, pharmacology and nutraceutics were discussed.

In this review, the relevance of the plant species belonging to the Pedicularis L. genus has been considered from different points of view. Particular emphasis was given to phytochemistry and ethnopharmacology, since several classes of natural compounds have been reported within this genus and many of its species are well known to be employed in the traditional medicines of many Asian countries. Some important conclusions on the chemotaxonomic and chemosystematic aspects of the genus have also been provided for the first time.

In this review article, the phytochemistry of the species belonging to the Araucariaceae family is explored. Among these, in particular, it is given a wide overview on the phytochemical profile of Wollemia genus, for the first time. In addition to this, the ethnopharmacology and the general biological activities associated to the Araucariaceae species are singularly described. Lastly, the chemotaxonomy at the genus and family levels is described and detailed.

In this paper, the phytochemical analysis on the inflorescences (flowers and bracts) of a sample of Tilia tomentosa collected from an isolated population in Central Italy, was reported for the first time. Thirteen compounds (oleanolic acid, maslinic acid, apigenin, luteolin, kaempferol, quercetin, kaempferol-3-O-glucoside, quercetin-3-O-glucoside, rutin, tiliroside, ellagic acid, shikimic acid and quinic acid), belonging to several different classes of natural products, were identified on the basis of spectroscopic and spectrometric analysis.

In this work, the secondary metabolite content of the EtOH extract of Kickxia spuria subsp. integrifolia (Brot.) R.Fern. is reported. Fourteen compounds were isolated and identified by means of column chromatography and NMR and MS instrumental techniques, respectively. Among the identified compounds, the chemotaxonomic markers of the species were evidenced, whereas others were reported for the first time in the genus. Among these, a new antirrhinoside derivative (12) was recognized.

In this work, an interesting application of phytochemistry for ethnopharmacological purposes was reported. In particular, the total phytochemical analysis of a single sample of Ajuga reptans L. (Lamiaceae) collected in Central Italy was carried out in order to provide a rationale for the use of this plant in folk medicine. This analysis was conducted on the volatile oil fraction by gas chromatography–mass spectroscopy (GC-MS) and on the polar one by means of classical column chromatography and nuclear magnetic resonance and MS.

In this work, the fifth part of an ongoing phytochemical study on Wollemia nobilis was reported. The attention was now focused on the male reproduction organs of which the content in both primary and secondary metabolites was analyzed. Twenty compounds, belonging to seven different classes of natural compounds, were identified from the ethanolic extract by means of Column Chromatography and NMR and MS Spectroscopy. They all represent new compounds for the studied organ whereas some of them are also new constituents of the genus or even previously undescribed phytochemicals.