TetraPh-Tol-BITIOPO: a new atropisomeric 3,3’-bithiophene based phosphine oxide as organocatalyst in Lewis Base-catalyzed Lewis Acid mediated reactions
A new chiral phosphine oxide based on 3,3’-bithiophene scaffold (tetraPh-Tol-BITIOPO) was synthesized, fully characterized
and separated into antipodes through chiral HPLC. This new compound was successfully employed as organocatalyst in Lewis
base-catalyzed Lewis acid mediated reactions involving trichlorosilyl compounds. The new atropisomeric catalyst was able
to promote the allylation of aldehydes with allyltrichlorosilane in up to 98% yield and up to 96% enantiomeric excess (ee),