MicroRNA-34a regulates the depression-like behavior in mice by modulating the expression of target genes in the Dorsal Raphè
Chronic or cumulative stress sustained over a long period of time increases the risk of affective illness. Mounting clinical and preclinical evidences support the involvement of the miR-34 family of microRNAs in stress-related psychiatric conditions and in the neurobiological mechanisms that underlie the regulation of stress response.